Protagonist Therapeutics, Inc (PTGX) Stock Analysis
Sector: Healthcare · Industry: Pharmaceutical Preparations
AnalystsStrong Buy20 analystsStrengths
- ✓Altman Z 142.9 — safe-zone balance sheet
Risks
- ⚠9 loss-making years in recent history
- ⚠Interest coverage -7.3× — thin debt cushion
What's happening with PTGX
Price History
5-Year Weekly Candlestick Chart
Profile
Strong financial health; growth, profitability, valuation and earnings quality lag behind.
How is each axis scored?
- Valuation20/100 · Weak
- P/E vs own history (n/a)10/25
- FCF yield (-1.3%)0/25
- P/S (32.7x)0/25
- EV/EBIT (n/a)10/25
- Growth0/100 · Weak
- Revenue CAGR (n/a)0/25
- Net income CAGR (n/a)0/25
- EPS CAGR 5Y (n/a)0/25
- Fwd implied growth (n/a)0/25
- Profitability0/100 · Weak
- ROIC (-104.5%)0/25
- ROE (-17.5%)0/25
- Net margin (-282.8%)0/25
- Operating margin (-343.6%)0/25
- Financial Health75/100 · Strong
- Altman Z (142.95)25/25
- Current ratio (17.76)25/25
- Interest coverage (-7.3x)0/25
- Net cash / debt (Net cash)25/25
- Quality35/100 · Weak
- Piotroski F (4/9)10/25
- Beneish M (n/a)0/25
- FCF conversion (103%)25/25
- Margin stability (σ 312.0%)0/25
About Protagonist Therapeutics, Inc
Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. Show more
The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.
Headquarters: NEWARK, CA · Employees: 141 · Website ↗
Insider Transactions
Recent SEC Form 4 filings
- SellOption exercise · filed 2026-09-10-7278 sh2026-09-10
- SellOpen market sale · filed 2026-09-10-7278 sh2026-09-10
- BuyOption exercise · filed 2026-09-10+7.3K sh2026-09-10
- SellOption exercise · filed 2026-09-10-63548 sh2026-09-09
- SellOpen market sale · filed 2026-09-10-63548 sh2026-09-09
+3 more recent filings
Key Metrics
Financial snapshot — pillar inputs plus per-share and market context
Valuation
20EP/E (TTM)—
Price / TTM EPS (own statements)
P/FCF42.2xC
Grade C: ExpensivePrice / Free Cash Flow per share (Finnhub). Inverse of FCF yield — negative when FCF is negative
FCF Yield-1.3%D
Grade D: NegativeTTM FCF / Market Cap — vs own 5Y history: -29.0%–13.0% · 53rd pct
P/S (TTM)32.74xD
Grade D: ExpensivePrice / TTM Revenue (own statements)
EV/EBITDA147.1xD
Grade D: ExpensiveEnterprise value / EBITDA (Finnhub) — capital-structure neutral
EV/Sales31.2xD
Grade D: Very expensiveEnterprise Value / TTM Revenue (Finnhub) — capital-structure neutral sales multiple
Forward P/E269.0xD
Grade D: ExpensivePrice / next-year EPS estimate — shows whether the TTM multiple is rich or just front-loading growth
P/B Ratio14.01xD
Grade D: Very expensivePrice to Book Value. Neg. equity = heavy buybacks
PEG Ratio2.91C
Grade C: ExpensiveFinnhub PEG — their P/E basis ÷ expected EPS growth. Suppressed when their P/E diverges >2× from our TTM P/E (different basis)
Dividend Yield—
TTM dividend yield (Finnhub) — annual dividends / price. None = no dividend; very high yield can signal distress
Payout Ratio—
Dividends / Net Income (Finnhub) — share of earnings paid out; >90% or negative = unsustainable
Profitability
0EROIC-104.5%D
Grade D: LowNOPAT (EBIT less ~21% tax) / invested capital (equity + debt − cash). Flagship quality metric — durable >15% signals a moat
ROE-17.5%D
Grade D: WeakReturn on Equity. Neg. equity = heavy buybacks
ROA11.2%A
Grade A: StrongReturn on Assets (Finnhub) — Net Income / Total Assets; how efficiently assets produce profit
Net Margin-282.8%D
Grade D: LowNet Income / Revenue
Operating Margin—
TTM EBIT / TTM Revenue
Gross Margin—
Gross Profit / Revenue
FCF Margin—
FCF / Revenue
True FCF Margin—
TTM (OCF − CapEx − SBC) / TTM Revenue — SBC treated as a real cost
Financial Health
75B+Altman Z-Score142.95A
Grade A: SafeBankruptcy risk. >3 Safe, <1.8 Distress
Current Ratio17.76xA
Grade A: HighCurrent Assets/Liabilities
Quick Ratio12.58xA
Grade A: High(Current Assets − Inventory) / Current Liabilities (Finnhub) — stricter liquidity test, excludes inventory
Interest Coverage-7.3xD
Grade D: RiskyEBIT/Interest. >10 Strong
Debt RepaymentNet CashA
Grade A: FastYears to repay net debt via FCF
Net Debt/EBIT—
Leverage. <2x Low, >4x High
Debt/Equity0.00xA
Grade A: LowDebt / Equity: <1 Conservative, >2 Risky. Not meaningful with non-positive equity; shown as unavailable rather than low debt.
Cash / Debt—
Cash covers how much of total debt. >1 = could repay all debt from cash
Growth
0ERevenue CAGR—
Compound annual revenue growth (up to 5Y depending on data availability)
Net Income CAGR—
Compound annual net income growth (up to 5Y depending on data availability)
EPS CAGR (5Y)—
Compound annual EPS growth over up to 5Y of per-share earnings (own statements). Null when either endpoint EPS ≤ 0
Implied EPS Growth—
Implied 1Y EPS growth from forward P/E vs our TTM EPS. Sparse — only where forward estimates exist
Dilution (5Y)—
Share count change over 5Y
SBC / Net Income—
Stock-based comp/Net income. >30% = dilution risk
SBC / Revenue—
TTM stock-based comp / TTM Revenue
Quality
9/10 Loss Years35DPiotroski F-Score4/9C
Grade C: AverageFinancial strength 0–9. >7 Strong
Beneish M-Score—
Earnings manipulation risk. < -2.22 Safe
FCF Conversion102.8%A
Grade A: StrongFCF / Net Income
Margin Stability312.0%D
Grade D: VolatileEBIT margin std deviation. Lower = stable
Capex / Revenue—
TTM CapEx / TTM Revenue — high % = capital-hungry business
Asset Turnover0.07xD
Grade D: LowRevenue / Total Assets (Finnhub) — how efficiently the asset base generates sales
More metrics — Per Share, Balance Sheet, MarketHide additional metrics
Per Share
EPS (TTM)—
TTM net income per share (Finnhub fallback)
Cash / Share$9.07
Cash & short-term investments per share (Finnhub)
Book Value / Share$9.82
Shareholders' equity per share (Finnhub). Negative = accumulated losses / heavy buybacks
Balance Sheet
Total Debt—
Total debt obligations (short + long term)
Cash & Equiv.$547.81M
Cash and short-term investments
Net Debt—
Total Debt minus Cash. Negative = Net Cash position
Total Equity$655.47M
Shareholders' equity (book value)
Asset / Liability16.61xA
Grade A: SolidTotal Assets / Total Liabilities
Market
Market Cap$9.18B
Current Market Capitalization
Beta1.18B
Grade B: MarketPrice sensitivity vs the market (Finnhub) — 1.0 moves with market, >1.2 amplifies swings
Takeaway
Company is effectively debt-free after netting cash.
How grades work: each metric is graded A–D against fixed thresholds (tap a row for the meaning). Card grades map the pillar score to A+–E — a card grade is that pillar's own score, not an average of the rows shown.
Financials as of Mar 2026 · Ratio snapshot Sep 26, 2026
Key Insights: Protagonist Therapeutics, Inc (PTGX)
Piotroski F-Score of 4/9 indicates mixed fundamentals for Protagonist Therapeutics, Inc. Altman Z-Score of 142.95 sits comfortably in the safe zone (≥ 2.99), indicating low bankruptcy risk. Company is effectively debt-free after netting cash.
- Interest coverage of -7.3× leaves little room for earnings shocks.
- Protagonist Therapeutics, Inc posted a net loss in 9 of 10 available completed fiscal years (2016–2025).
- At a valuation score of 20/100, PTGX trades at a premium to its historical multiples.
See how PTGX ranks on the Capex Tracker — top 50 capital spenders compared.
Recent Market Moves
See all PTGX moves →| Date | Session | Price | Move | Z-Score |
|---|---|---|---|---|
| Sep 25 | Regular | 141.84 | +3.28% | 2.07 |
| Sep 25 | After-hours | 141.86 | +3.29% | 2.08 |
| Sep 23 | Regular | 139.11 | -4.11% | -2.64 |
| Sep 23 | After-hours | 138.70 | -4.39% | -2.84 |
Frequently Asked Questions about PTGX
Is PTGX stock a buy right now?
PreMarketPrice's quantitative model rates Protagonist Therapeutics, Inc's financial health at 75/100. This is a data-driven snapshot of fundamentals, not investment advice.
Is PTGX stock overvalued?
Protagonist Therapeutics, Inc trades at a trailing P/E of n/a and our valuation score rates it 20/100 (higher = cheaper vs. its own history). See the Valuation History and Key Metrics sections for forward P/E, EV/EBITDA and PEG context.
When does Protagonist Therapeutics, Inc report earnings?
No confirmed earnings date is currently scheduled for PTGX. The Earnings section lists recent reports and updates as dates are announced.
What sector does Protagonist Therapeutics, Inc operate in?
Protagonist Therapeutics, Inc operates in the Healthcare sector, within the Pharmaceutical Preparations industry. The Related Stocks section lists sector peers for comparison.
What does Protagonist Therapeutics, Inc do?
Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform.
About Protagonist Therapeutics, Inc (PTGX) Stock
Protagonist Therapeutics, Inc (PTGX) is a US-listed stock operating in the Healthcare sector, specifically the Pharmaceutical Preparations industry. Real-time pricing data for Protagonist Therapeutics, Inc is available on this page with a market capitalization of $9.2 billion. The financial health score for PTGX is 75/100, which indicates excellent financial strength based on profitability, leverage, liquidity, and growth metrics. This page provides real-time pre-market pricing, earnings calendar, financial health analysis, and valuation metrics for PTGX stock.
PTGX Stock Analysis & Key Metrics
On PreMarketPrice, you can track Protagonist Therapeutics, Inc (PTGX) across multiple dimensions:
- Pre-market price & movement: Real-time PTGX stock price with percentage change, updated continuously during pre-market and regular trading hours.
- Valuation & P/E history: Historical P/E, P/S, and P/B ratios for PTGX with trend analysis and normalized valuation multiples.
- Financial statements: Revenue, net income, assets, liabilities, and equity for Protagonist Therapeutics, Inc across multiple reporting periods.
- Financial health score: A composite score of 75/100 based on Altman Z-Score, Piotroski F-Score, profitability, and leverage metrics for PTGX.
- Sector peers: Compare PTGX against 10 other healthcare stocks on key financial metrics.
Is PTGX a Good Stock to Buy?
This page provides data-driven analysis to help you evaluate Protagonist Therapeutics, Inc (PTGX) as an investment. The financial health score of 75/100 suggests excellent financial fundamentals. Valuation metrics show whether the stock is trading above or below its historical average.However, this is not financial advice — always do your own research before investing.
Data on this page is sourced from real-time market feeds, Polygon.io, and Finnhub.Protagonist Therapeutics, Inc (PTGX) trades on NYSE/NASDAQ. Pre-market trading occurs 4:00 AM – 9:30 AM ET. Regular market hours are 9:30 AM – 4:00 PM ET.