Historical pre-market losers from Tuesday, September 8, 2026. 50 stocks declined in pre-market trading. Biggest decliner: Novartis AG (NVS) at -13.00%.
Pre-market losers are stocks experiencing the largest price drops between 4:00 AM and 9:30 AM ET. These moves are often triggered by earnings misses, guidance cuts, analyst downgrades, or negative macro developments. Low pre-market volume can amplify these moves beyond what regular-session trading would produce.
Significant pre-market declines can present either warning signs or buying opportunities depending on the catalyst. Cross-reference with the earnings calendar and individual stock analysis pages for deeper context.
| Ticker | Company | Sector | Price | % Change |
|---|---|---|---|---|
| NVS | Novartis AG | Healthcare | $139.19 | -13.00% |
| AMGN | Amgen Inc | Healthcare | $412.40 | -5.68% |
| HWM | Howmet Aerospace Inc. | Industrials | $246.99 | -4.74% |
| ALNY | Alnylam Pharmaceuticals, Inc. | Healthcare | $253.55 | -4.72% |
| LNG | Cheniere Energy Inc | Energy | $282.09 | -3.39% |
| TECH | Bio-Techne Corp. | Healthcare | $70.13 | -3.18% |
| ARGX | argenx SE American Depositary Shares | Other | $1002.23 | -2.99% |
| SONY | Sony Group Corporation American Depositary Shares (Each Representing One Share of Dollar Validated Common Stock) | Comm Serv | $23.89 | -2.74% |
| MSTR | Strategy Inc Common Stock Class A | Technology | $139.20 | -2.52% |
| HLN | Haleon plc American Depositary Shares (Each representing two Ordinary Shares) | Other | $9.37 | -2.40% |
| TEAM | Atlassian Corporation Class A Common Stock | Technology | $185.06 | -2.38% |
| SHOP | Shopify Inc. Class A subordinate voting shares | Technology | $141.90 | -2.20% |
| HMC | Honda Motor Co., Ltd. American Depositary Share, each representing three (3) shares of Common Stock | Cons Cyclical | $31.98 | -2.11% |
| VRTX | Vertex Pharmaceuticals Inc | Healthcare | $535.00 | -2.04% |
| SNY | Sanofi American Depositary Shares (Each representing one-half of one ordinary share) | Healthcare | $43.40 | -1.90% |
| NOW | SERVICENOW, INC. | Technology | $138.60 | -1.88% |
| NVO | Novo-Nordisk A/S | Healthcare | $45.74 | -1.85% |
| MAN | ManpowerGroup | Other | $60.85 | -1.82% |
| IBN | ICICI Bank Limited | Other | $29.75 | -1.82% |
| CMG | Chipotle Mexican Grill, Inc. | Cons Cyclical | $36.30 | -1.79% |
| JNJ | Johnson & Johnson | Healthcare | $270.50 | -1.72% |
| INTU | Intuit Inc | Technology | $327.00 | -1.71% |
| GBTC | Grayscale Bitcoin Trust ETF | Financial Services | $60.69 | -1.68% |
| BBY | Best Buy Company, Inc. | Cons Cyclical | $88.75 | -1.68% |
| GSK | GSK plc American Depositary Shares (Each representing two Ordinary Shares) | Healthcare | $49.06 | -1.67% |
| GILD | Gilead Sciences Inc | Healthcare | $148.50 | -1.65% |
| ADBE | Adobe Inc. | Technology | $262.20 | -1.62% |
| CME | CME Group Inc. | Financial Services | $276.92 | -1.55% |
| BNTX | BioNTech SE American Depositary Share | Healthcare | $102.15 | -1.55% |
| ZTO | ZTO Express (Cayman) Inc. American Depositary Shares, each representing one Class A ordinary share | Other | $20.63 | -1.53% |
| JD | JD.com, Inc. | Other | $27.83 | -1.52% |
| ACN | Accenture PLC | Technology | $183.88 | -1.52% |
| ADSK | Autodesk Inc | Technology | $214.70 | -1.47% |
| XYZ | Block, Inc. | Technology | $81.57 | -1.44% |
| SWK | Stanley Black & Decker, Inc. | Industrials | $95.97 | -1.43% |
| WDAY | Workday, Inc. Class A Common Stock | Technology | $193.00 | -1.42% |
| VEEV | Veeva Systems Inc. | Technology | $271.20 | -1.41% |
| AEE | Ameren Corporation | Utilities | $104.97 | -1.41% |
| TM | Toyota Motor Corporation American Depositary Shares (Each representing ten Ordinary Shares) | Cons Cyclical | $194.34 | -1.41% |
| KVYO | Klaviyo, Inc. | Technology | $18.35 | -1.40% |
| CCOI | Cogent Communications Holdings, Inc. | Technology | $9.91 | -1.39% |
| INFY | Infosys Limited American Depositary Shares | Other | $11.54 | -1.38% |
| DDOG | Datadog, Inc. Class A Common Stock | Technology | $210.00 | -1.38% |
| ZS | Zscaler, Inc. Common Stock | Technology | $167.50 | -1.35% |
| CRM | Salesforce, Inc. | Technology | $255.74 | -1.35% |
| PFE | Pfizer Inc. | Healthcare | $28.07 | -1.34% |
| MRNA | Moderna, Inc. Common Stock | Healthcare | $143.61 | -1.33% |
| CRCL | Circle Internet Group, Inc. | Financial Services | $100.69 | -1.33% |
| DOCU | DocuSign, Inc. Common Stock | Technology | $67.50 | -1.33% |
| EL | The Estee Lauder Companies Inc. Class A | Cons Defensive | $102.50 | -1.31% |